A Clinical Pilot Study Showing the Safety and Efficacy of Intramuscular Injection of Atelocollagen for Prevention of Paraspinal Muscle Atrophy after Spine Surgery

Objective: The objective of this study was to assess the safety and efficacy intramuscular injection atelocollagen for prevention paraspinal muscle atrophy after spine surgery. Atelcollagen has been widely used as an intradermal filler restore soft tissue defect. Many studies demonstrated that provides good therapeutic results by promoting cell proliferation enhances healing effect on injured connective tissues such tendons fasciae, while causing few complications. Methods: A total 118 patients who underwent single level posterior lumbar interbody fusion (PILF) between December 2017 April 2019 were retrospectively reviewed. In group 60 patients, 3 mL gel-type 3% solution prepared injected into multifidus during wound closure. Clinical evaluated improvement back pain, elevation a enzyme, inflammatory markers. Radiologic with comparison density cross-sectional area (CSA) erector spinae in CT images. Results: Visual analogue scale (VAS) scores pain not significantly lower postoperatively compared control group. reduction postoperative CSA serum enzyme markers No major procedure-related complications observed follow-up period.Conclusion: Intramuscular is safe feasible This novel method seems advantageous accelerating without inflammation.